Motilin Receptor
MLNR
Motilin receptor is a G protein-coupled receptor that binds motilin. Motilin in turn is an intestinal peptide that stimulates contraction of gutsmooth muscle. The main function of motilin is to increase the migrating myoelectric complex component of gastrointestinal motility and stimulate the production of pepsin. Motilin is called "housekeeper of the gut" because it improves peristalsis in the small intestine and clears out the gut to prepare for the next meal. A high level of motilin secreted between meals into the blood stimulates the contraction of the fundus and antrum and accelerates gastric emptying. It then contracts the gallbladder and increases the squeeze pressure of the lower esophageal sphincter. Other functions of motilin include increasing the release of pancreatic polypeptide and somatostatin.
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Motilin Receptor 関連製品 (18)
関連製品 (18)
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Motilin (26-47), human, porcine
(Motilin (26-47), human, porcine)
0 Images製品番号: HY-P1037CAS 番号: 52906-92-0Motilin (26-47), human, porcine is an endogenous motilin receptor ligand with Ki and EC50 of 2.3 nM and 0.3 nM in a Chinese hamster ovary cell line.
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MA-2029
0 ImagesMA-2029 is a selective, orally active, and competitive motilin receptor antagonist (IC50=4.9 nM). MA-2029 is selective for the motilin receptor over various other receptors and ion channels. MA-2029 may be useful for gastrointestinal disorders associated with disturbed gastrointestinal motility.
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DS-3801b
0 ImagesDS-3801b is a potent and non-macrolide agonist of GPR38. DS-3801b is expected to be novel gastrointestinal prokinetic agents for the research of functional gastrointestinal disorders such as gastroparesis and chronic constipation.
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Motilin, human, porcine
0 ImagesMotilin, human, porcine is a gastrointestinal hormone, which is released during fasting and after eating, or by drinking water. Motilin, human, porcine promotes enteric cholinergic activity in human stomach with an EC50 of 33 nM, and thus modulates gastrointestinal motility function.
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Motilin, canine
0 Images別名: Motilin (canine)Motilin, canine is a 22-amino acid peptide. Motilin is a potent agonist for gastrointestinal smooth muscle contraction.
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ME67
0 Images製品番号: HY-187989CAS 番号: 33275-72-8別名: EM-B enol etherME67 (EM-B enol ether) is a motilin receptor (Motilin Receptor) agonist with pIC50 values of 8.38 and 6.49 for rabbit and human motilin receptors, respectively. ME67 activates the G protein-coupled Motilin Receptor, inducing calcium mobilization, calcium flux, receptor internalization, and gastrointestinal motility. ME67 can be used in research on gastrointestinal motility disorders.
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ME36
0 Images製品番号: HY-187988CAS 番号: 110469-03-9別名: N-methyl EM-AME36 (N-methyl EM-A) is a motilin receptor agonist that induces calcium mobilization, with a pIC50 of 7.58 for the rabbit motilin receptor. ME36 can be used in research on digestive system diseases.
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KC-11458
0 Images製品番号: HY-105333CAS 番号: 151052-43-6KC-11458 is a motilin agonist. KC-11458 can accelerate gastric emptying.
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[Leu13]-Motilin
![[Leu13]-Motilin](https://file.medchemexpress.com/product_pic/hy-106323.gif "Click to View [Leu13]-Motilin Product Detail")
0 Images製品番号: HY-106323CAS 番号: 59530-69-7別名: KW-5139[Leu13]-Motilin (KW-5139) is a motilin analogue. [Leu13]-Motilin stimulates gastrointestinal motility in the rabbit. [Leu13]-Motilin causes concentration-dependent contractions of the gastric antrum, duodenum, jejunum, ileum and the descending colon in vitro.
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ANQ-11125
0 Images製品番号: HY-P1233CAS 番号: 153966-48-4ANQ-11125 is a potent and selective antagonist of motilin, with the pKd of 8.24. ANQ-11125 blocks motilide-induced contractions in vitro in the rabbit.
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Mitemcinal fumarate
0 Images製品番号: HY-106018ACAS 番号: 154802-96-7別名: GM 611 fumarateMitemcinal fumarate is an oral motilium agonist. Studies in rabbits and dogs have shown that it can promote defecation without causing severe diarrhea, increase stool weight without increasing water content in the rabbit constipation model, and reduce the time to first defecation in dogs. Mitemcinal fumarate may be a constipation suppressant due to its early onset and short duration of action.
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EM-523
0 Images製品番号: HY-106327CAS 番号: 110205-60-2EM-523 is a motilin agonist and an erythromycin derivative. EM-523 has pED50 values of 8.19 and 6.08 for promoting contractions in rabbit small intestinal tissue and human duodenal tissue, respectively. EM-523 can be used in the research of gastrointestinal diseases.
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Mitemcinal
0 Images製品番号: HY-106018CAS 番号: 154738-42-8別名: GM 611Mitemcinal (GM 611) is an oral motilin receptor agonist. Studies in rabbits and dogs have shown that it can promote defecation without causing severe diarrhea, increase stool weight without increasing water content in the rabbit constipation model, and reduce the time to first defecation in dogs. Mitemcinal may be a constipation suppressant due to its early onset and short duration of action.
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EM574
0 Images製品番号: HY-105263CAS 番号: 110480-13-2EM574 is a potent motilin receptor agonist in the human gastric antrum and rabbit gastrointestinal tract in vitro. EM574 is an erythromycin derivative.
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[Nle13]-Motilin
![[Nle13]-Motilin](https://file.medchemexpress.com/product_pic/hy-p3680.gif "Click to View [Nle13]-Motilin Product Detail")
0 Images製品番号: HY-P3680CAS 番号: 55524-56-6[Nle13]-Motilin, a motilin analogue, is a motilin receptor agonist.
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Atilmotin
0 Images製品番号: HY-106258CAS 番号: 533927-56-9別名: OHM 11638; BAX-ACC 1638; MOT 288OHM 11638 (Atilmotin), an analogue of the (1-14) fragment of porcine motilin, is a motilin receptor agonist with a pKd of 8.94 for the motilin receptor. OHM 11638 affects esophageal, lower esophageal sphincter (LES), and gastric motility. OHM 11638 increases LES and gastric pressures, OHM 11638 can be used as prokinetic agents.
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RWJ-68022
0 Images製品番号: HY-171853CAS 番号: 223442-22-6RWJ-68022 (Example 9) is a cyclopentene derivative and a motilin receptor antagonist. RWJ-68022 can compete with motilin and erythromycin for the motilin receptor site. RWJ-68022 can be used in the research of gastrointestinal-related diseases.
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